: Blessingway . Leland C. Wyman.

Arlene R . Wyman , Linda

The growth of clones of human genomic DNA fragments in a bacteriophage X vector has been examined in a number of different Escherichia coli hosts. A large proportion (8.9%) of the phages carrying different fragments of the human genome fail to grow on standard rec' hosts but will grow on hosts carrying mutations in the recB, recC, and sbcB genes. Heteroduplex analysis in the electron microscope...

The Board of Trustees of the Leland

Mitochondrial DNA : State of Tennessee v . Paul Ware By C . Leland Davis

CASE SYNOPSIS In September 1996, a new evidence tool was used for the first time in a United States courtroom. Mitochondrial DNA (mtDNA) evidence was introduced in a Tennessee murder prosecution against twenty-seven-year-old Paul Ware. Without the mtDNA results there was only circumstantial evidence pointing to Ware as the suspect in the rape and murder of a fouryear-old girl. The defense claim...

Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants.

We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration ([EC50]), and effective Hill coefficient, and explore the full spectrum of phenotypes that are accessible...

An Extension of Some Results Due to Cox and Leland

We investigate an optimal portfolio allocation problem between a risky and a risk-free asset, as in [1]. They obtained explicit conditions for path-independence and optimality of allocation strategies when the price of the risky asset follows a geometric Brownian motion with constant asset characteristics. This paper analyzes and extends their results for dynamic investment strategies by allowi...